The group B match went down at Japoma Stadium in Douala on Thursday when the Leopards of the DR Congo met the Libya Mediterranean Knights in a game that ended in a 1-1 draw.
DR Congo suffered a series of pre-match blows when coach Florent Ibenge, goalkeepers Ley Matampi and Guy-Serge Mukumi, defender Andy Bikoko and midfielder Doxa Gikanji tested positive for coronavirus.
After playing a goalless draw against Niger in their opening group B match on Sunday, the Mediterranean Knights of Libya still maintained the flow when they drew a goal each with the Red Devils of the Republic of Congo.
DR Congo now lead group B with 4 points, Niger and Libya share 2 points each and Republic of Congo secured one point.
Friday matches will feature group C matches where the leaders Morocco will face Rwanda and later Uganda Cranes to meet Togo. A win for Morocco will secure a direct ticket to the quarter-finals.
Morocco and Uganda seem to be the favourite to lead group C but the Rwanda team can still outperform Morocco in Friday match.