Ghana, their opponents on Friday night, have never gone this far in the tournament before, having reached the second round four years ago on their FIFA World Cup debut.

In both 2006 and in South Africa, the Black Stars were Africa's only representatives in the knock-out rounds, and they can also become the first ever side from the continent to advance to a semi-final with a win. Standing in the way of Africa's hopes is an in-form La Celeste led by one of the most dynamic front-lines at the tournament.

The match

Uruguay-Ghana, Johannesburg (Soccer City), 2 July, 20.30

For a team that struggled to qualify for the finals, Uruguay emerged as one of the dark horses of the opening stage after finishing top of Group A. After opening the event with a scoreless draw with France, they have secured three consecutive wins, largely thanks to the form of strikers Diego Forlan and Luis Suarez. Forlan scored a brace in the 3-0 dismantling of the hosts, while Suarez scored the trio of Uruguay's goals in the 1-0 win over Mexico and 2-1 victory over Korea Republic. Edinson Cavani is the most unheralded of the attacking triumvirate, but the Palermo forward can also be lethal if unchecked.

However, Ghana coach Milovan Rajevac has earned a reputation for his tactical acumen, and the Serb has built one of Africa's finest defences.

With so much history on the line, Ghana could be forgiven for being overawed with the occasion, but the Black Stars are seemingly unflappable despite being the youngest team in the tournament. A side boasting several players who won the FIFA U-20 World Cup last year, they finished runners-up at January's CAF Africa Cup of Nations on the back of three consecutive 1-0 wins. They also held their nerve in a dramatic 2-1 extra-time victory over South Africa 2010's comeback kings, USA, in the second round.

Asamoah Gyan has scored three of the side's four goals, and despite being hampered by an ankle injury, should be the fulcrum of the Ghana attack. Kevin-Prince Boateng also appears likely to win his fitness race, though the loss of starlet Andre Ayew to suspension will be painful. The door might now be open for the comeback of little-used Inter Milan midfielder Sulley Muntari, and the possible return of previously injured centre-half Isaac Vorsah could also be a major boost.

Players to watch

Luis Suarez v John Mensah

A veteran anchor at the back for Ghana, John Mensah will need to call on all of his experience to stop the speed and creativity of the Uruguay attack. The 23-year-old Ajax striker Suarez is technically adept and capable of scoring from anywhere around the box. Although the powerful Mensah should have the advantage in the air, he could well be challenged for pace on the counter-attack, though the potential return of Vorsah could provide him with significant assistance.

The stat

7 – Asamoah Gyan has scored seven goals for Ghana out of the 11 they have tallied in full international matches in 2010. Ayew, Boateng, Muntari and Quincy Owusu-Abeyie have claimed the others.

What they said

"They are fast, strong, and they have done well in other games, even against Germany," Diego Forlan, Uruguay forward.
"They have a great team, especially in attack. This is what we have to watch out for because they have players like Forlan and Suarez," Asamoah Gyan, Ghana striker.
Voice of the fans
"Both teams have impressed me. Ghana has shown speed and a great ability to pass. Their defence is not the best but their ability to fire an attack has shown. I think that the first side to score will win. In this case, Ghana will pull through," FIFA.com user OnTarget06.

The question

Can Ghana eclipse Cameroon's exploits in 1990 and Senegal's in 2002 to become the first African side in the last four? Or will the two-time champions Uruguayans keep their good run going in a tournament where the South American teams have been immensely difficult to beat?

After a two-day lull, the action restarts at Nelson Mandela Bay Stadium in Port Elizabeth where five-times champions Brazil take on a Netherlands who have failed to lift the trophy despite fielding some of the most eye-catching teams ever.